Malarial fever: Hemozoin is involved but Toll-free
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چکیده
منابع مشابه
Malarial fever: hemozoin is involved but Toll-free.
T he gospel of Matthew (chapter 8, verse 14) reports that ‘‘Peter’s mother-in-law was sick of the fever,’’ and many commentaries think that this close relative of the apostle living in the Galilee 2,000 years ago was suffering from malaria. The main characteristic of malaria is fever, and periodic fevers have been reported even 3,000 years ago in early Chinese, Chaldean, Hindu, Egyptian, and Gr...
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BACKGROUND Characteristic symptoms of malaria include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome. Plasmodium species produce a crystal called hemozoin that is generated by detoxification of heme after hemoglobin degradation in infected red blood cells. Thus, we hypothesized that hemozoin could activate the Nalp3 inf...
متن کاملThe interaction of artemisinin with malarial hemozoin.
[14C]Artemisinin was taken up by Plasmodium falciparum in culture and concentrated in hemozoin. In vitro, hemin and artemisinin were found to undergo a chemical reaction forming two major products which were isolated by high-performance liquid chromatography (HPLC). The m/z values of the two products were 856 and 871. Thin-layer chromatography (TLC) and HPLC of hemozoin isolated from [14C]artem...
متن کاملMalarial Pigment Hemozoin and the Innate Inflammatory Response
Malaria is a deadly infectious disease caused by the intraerythrocytic protozoan parasite Plasmodium. The four species of Plasmodium known to affect humans all produce an inorganic crystal called hemozoin (HZ) during the heme detoxification process. HZ is released from the food vacuole into circulation during erythrocyte lysis, while the released parasites further infect additional naive red bl...
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Severe malarial anemia is the most common syndrome of severe malaria in endemic areas. The pathophysiology of chronic malaria is characterised by a striking degree of abnormal development of erythroid precursors (dyserythropoiesis) and an inadequate erythropoietic response in spite of elevated levels of erythropoietin. The cause of dyserythropoiesis is unclear although it has been suggested tha...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0610874104